Search results for "Smooth Muscles"

showing 2 items of 2 documents

Mechanical strain causes adaptive change in bronchial fibroblasts enhancing profibrotic and inflammatory responses

2016

Asthma is characterized by periodic episodes of bronchoconstriction and reversible airway obstruction; these symptoms are attributable to a number of factors including increased mass and reactivity of bronchial smooth muscle and extracellular matrix (ECM) in asthmatic airways. Literature has suggested changes in cell responses and signaling can be elicited via modulation of mechanical stress acting upon them, potentially affecting the microenvironment of the cell. In this study, we hypothesized that mechanical strain directly affects the (myo)fibroblast phenotype in asthma. Therefore, we characterized responses of bronchial fibroblasts, from 6 normal and 11 asthmatic non-smoking volunteers,…

MalePulmonologyPulmonary FibrosisAdult; Asthma; Biomechanical Phenomena; Bronchi; Case-Control Studies; Female; Fibroblasts; Humans; Male; Pneumonia; Pulmonary Fibrosis; Stress Mechanical; Medicine (all); Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)Glycobiologylcsh:MedicinePathology and Laboratory MedicineBiochemistryAnimal CellsMedicine and Health Scienceslcsh:ScienceImmune ResponseMusculoskeletal SystemConnective Tissue CellsSmooth MusclesMusclesMedicine (all)Extracellular MatrixBiomechanical PhenomenaConnective TissueFibroblastProteoglycansFemaleCellular TypesAnatomyCellular Structures and OrganellesCase-Control StudieResearch ArticleHumanAdultPulmonary FibrosiImmunologyBronchiSigns and SymptomsExtraction techniquesDiagnostic MedicineHumansInflammationBiochemistry Genetics and Molecular Biology (all)Settore BIO/16 - Anatomia Umanalcsh:RBiology and Life SciencesProteinsCell BiologyPneumoniaFibroblastsRNA extractionAsthmaResearch and analysis methodsBiological TissueAgricultural and Biological Sciences (all)Case-Control Studieslcsh:QStress MechanicalCollagens
researchProduct

Domain-specific transfer learning in the automated scoring of tumor-stroma ratio from histopathological images of colorectal cancer

2023

Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional neural networks which were trained to classify colorectal cancer tissue in hematoxylin-eosin stained samples into three classes: stroma, tumor and other. The models were trained using a data set that consists of 1343 whole slide images. Three different training setups were applied with a transfer learning approach using domain-specific data i.e. an external colorectal cancer histopathological data set. The three most accurate models were chosen as a classifie…

FOS: Computer and information sciencessmooth musclesvisionComputer Science - Machine LearningMultidisciplinaryComputer Vision and Pattern Recognition (cs.CV)Computer Science - Computer Vision and Pattern Recognitioncolorectal cancerforecastingennusteetneuroverkotsuolistosyövätneural networksQuantitative Biology - Quantitative MethodsMachine Learning (cs.LG)machine learningkoneoppiminenFOS: Biological sciencessyöpätauditcancers and neoplasmsmalignant tumorsQuantitative Methods (q-bio.QM)
researchProduct